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Diabetic Macular Edema

Diabetic Macular Edema (DME) is a common manifestation of Diabetic Retinopathy (DR, one of the most common complications of diabetes mellitus), and a cause of serious central visual loss and impairment in diabetic patients if left untreated.

In China, over 60mn people will have DM by 2030, and 10% -20% of them will develop DR, among them, ~10% will progress to DME.

IVT anti-VEGF is the first-line treatment for DME, however it has 30%-40% non-responsive rate. The frequent injection also brings huge burden for patients; Intravitreal steroid injection is also used as an alternative treatment, while side effects of ocular steroid  (cataract and increased IOP) are always concerning.