ARVN701 (iTEAR®100) is an FDA cleared, non-invasive, drug-free neurostimulation device designed for the treatment of DED. Being the first neurostimulator to stimulate tear secretion through non-invasive stimulation of the external nasal nerve, the device offers immediate relief with natural tear production as well as increasing the level of basal tear secretion. Neurostimulation can also, improve the secretion function from the meibomian glands. In the pivotal study, iTEAR®100 showed sustained tear production and improvements in symptomatology with favorable safety and usability.
 Ji MH, Moshfeghi DM, PerimanL,KadingD,Matossian C, Walman G, MarkhamS, MuA, Jayaram A, Gertner M, Karpecki P, Friedman NJ. Novel extranasal tear stimulation: Pivotal study results. Trans Vis Sci Tech. 2020;9(12):23.